Stephen Liberles

Stephen Liberles, Ph.D.

Professor of Cell Biology, Harvard Medical School
Tutor in Molecular and Cellular Biology, Faculty of Arts & Sciences
HHMI Investigator

Stephen Liberles, Ph.D. is a Professor and HHMI Investigator in the Cell Biology Department at Harvard Medical School. Dr. Liberles received an undergraduate degree in Chemistry from Harvard in 1994, and a Ph.D. in Chemistry and Chemical Biology from Harvard in 1999, working in the lab of Stuart Schreiber. He then performed post-doctoral work in the lab of Linda Buck, first at Harvard Medical School and then at the Fred Hutchinson Cancer Research Center in Seattle.

The Liberles Lab focuses on the molecular neuroscience of sensory systems, including olfaction, pheromone sensing, taste, and internal organ senses of the vagus nerve. Some discoveries from his lab include characterizing non-classical families of olfactory receptors, odors and pheromones that stimulate innate behaviors, vagus nerve cell types that selectively control autonomic physiology, and mechanisms underlying sensation within internal organs, including airway stretch and changes in aortic blood pressure.

Harvard Medical School

Dept. of Cell Biology, LHRRB 601A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7283

Lab fax: 617-432-7285

Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.
Authors: Authors: Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM.
Nat Med
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Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.
Authors: Authors: Nonomura K, Woo SH, Chang RB, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A.
Nature
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Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse.
Authors: Authors: Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.
J Neurosci
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Sensory Neurons that Detect Stretch and Nutrients in the Digestive System.
Authors: Authors: Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD.
Cell
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State-dependent responses to sex pheromones in mouse.
Authors: Authors: Stowers L, Liberles SD.
Curr Opin Neurobiol
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Non-classical amine recognition evolved in a large clade of olfactory receptors.
Authors: Authors: Li Q, Tachie-Baffour Y, Liu Z, Baldwin MW, Kruse AC, Liberles SD.
Elife
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Trace amine-associated receptors: ligands, neural circuits, and behaviors.
Authors: Authors: Liberles SD.
Curr Opin Neurobiol
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The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Authors: Authors: Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R.
Nat Med
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Vagal Sensory Neuron Subtypes that Differentially Control Breathing.
Authors: Authors: Chang RB, Strochlic DE, Williams EK, Umans BD, Liberles SD.
Cell
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Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
Authors: Authors: Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C.
Elife
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