Stephen Liberles

Stephen Liberles, Ph.D.

Professor of Cell Biology, Harvard Medical School
Tutor in Molecular and Cellular Biology, Faculty of Arts & Sciences

Stephen Liberles, Ph.D. is a Professor and HHMI Investigator in the Cell Biology Department at Harvard Medical School. Dr. Liberles received an undergraduate degree in Chemistry from Harvard in 1994, and a Ph.D. in Chemistry and Chemical Biology from Harvard in 1999, working in the lab of Stuart Schreiber. He then performed post-doctoral work in the lab of Linda Buck, first at Harvard Medical School and then at the Fred Hutchinson Cancer Research Center in Seattle.

The Liberles Lab focuses on the molecular neuroscience of sensory systems, including olfaction, pheromone sensing, taste, and internal organ senses of the vagus nerve. Some discoveries from his lab include characterizing non-classical families of olfactory receptors, odors and pheromones that stimulate innate behaviors, vagus nerve cell types that selectively control autonomic physiology, and mechanisms underlying sensation within internal organs, including airway stretch and changes in aortic blood pressure.

Harvard Medical School

Dept. of Cell Biology, LHRRB 601A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7283

Lab fax: 617-432-7285

Brain-body physiology: Local, reflex, and central communication.
Authors: Authors: Sammons M, Popescu MC, Chi J, Liberles SD, Gogolla N, Rolls A.
Cell
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Publisher Correction: Krause corpuscles are genital vibrotactile sensors for sexual behaviours.
Authors: Authors: Qi L, Iskols M, Greenberg RS, Xiao JY, Handler A, Liberles SD, Ginty DD.
Nature
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Vagal TRPV1 + sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection.
Authors: Authors: Yang D, Almanzar N, Xia J, Udit S, Yeung ST, Khairallah C, Hoagland DA, Umans BD, Sarden N, Erdogan O, Baalbaki N, Beekmayer-Dhillon A, Lee J, Meerschaert KA, Liberles SD, Yipp BG, Franklin RA, Khanna KM, Baral P, Haber AL, Chiu IM.
bioRxiv
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A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut.
Authors: Authors: Zhu Y, Meerschaert KA, Galvan-Pena S, Bin NR, Yang D, Basu H, Kawamoto R, Shalaby A, Liberles SD, Mathis D, Benoist C, Chiu IM.
Science
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Stimulating intestinal GIP release reduces food intake and body weight in mice.
Authors: Authors: Lewis JE, Nuzzaci D, James-Okoro PP, Montaner M, O'Flaherty E, Darwish T, Hayashi M, Liberles SD, Hornigold D, Naylor J, Baker D, Gribble FM, Reimann F.
Mol Metab
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Krause corpuscles are genital vibrotactile sensors for sexual behaviours.
Authors: Authors: Qi L, Iskols M, Greenberg RS, Xiao JY, Handler A, Liberles SD, Ginty DD.
Nature
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A vagal reflex evoked by airway closure.
Authors: Authors: Schappe MS, Brinn PA, Joshi NR, Greenberg RS, Min S, Alabi AA, Zhang C, Liberles SD.
Nature
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A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling.
Authors: Authors: Hamacher C, Degen R, Franke M, Switacz VK, Fleck D, Katreddi RR, Hernandez-Clavijo A, Strauch M, Horio N, Hachgenei E, Spehr J, Liberles SD, Merhof D, Forni PE, Zimmer-Bensch G, Ben-Shaul Y, Spehr M.
Curr Biol
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Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Authors: Authors: Lowenstein ED, Ruffault PL, Misios A, Osman KL, Li H, Greenberg RS, Thompson R, Song K, Dietrich S, Li X, Vladimirov N, Woehler A, Brunet JF, Zampieri N, Kühn R, Liberles SD, Jia S, Lewin GR, Rajewsky N, Lever TE, Birchmeier C.
Neuron
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Structural basis of amine odorant perception by a mammal olfactory receptor.
Authors: Authors: Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP.
Nature
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