Sichen Shao

Sichen (Susan) Shao, Ph.D.

Associate Professor of Cell Biology (HMS)

Sichen (Susan) Shao, Ph.D., joined Harvard Medical School in 2016. Susan received her Ph.D. in biological sciences from the NIH graduate partnerships program with Johns Hopkins University. She then performed postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, UK.

The Shao Lab studies cellular mechanisms that surveil different steps of protein biosynthesis to regulate gene expression and maintain protein homeostasis. How quality control factors distinguish rare aberrant products from similar biosynthetic intermediates is a fundamental problem in biomedical science. The Shao Lab biochemically reconstitutes quality control pathways that act on ribosomes during protein synthesis and that sort membrane proteins to different organelles. Combining these experimental systems with mechanistic and structural approaches generates molecular-level insights into physiological processes essential for cell survival, proliferation, and differentiation.

Harvard Medical School

Dept. of Cell Biology, C-448

240 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1067

STING cyclic dinucleotide sensing originated in bacteria.
Authors: Authors: Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ.
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The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Authors: Authors: McKenna MJ, Sim SI, Ordureau A, Wei L, Harper JW, Shao S, Park E.
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CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.
Authors: Authors: Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ.
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ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.
Authors: Authors: Yip MCJ, Savickas S, Gygi SP, Shao S.
Cell Rep
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Mechanism for recycling tRNAs on stalled ribosomes.
Authors: Authors: Yip MCJ, Keszei AFA, Feng Q, Chu V, McKenna MJ, Shao S.
Nat Struct Mol Biol
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Structures of translationally inactive mammalian ribosomes.
Authors: Authors: Brown A, Baird MR, Yip MC, Murray J, Shao S.
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Ribosomes and cryo-EM: a duet.
Authors: Authors: Brown A, Shao S.
Curr Opin Struct Biol
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In vitro reconstitution of translational arrest pathways.
Authors: Authors: Feng Q, Shao S.
View full abstract on Pubmed