Pere Puigserver
Pere Puigserver, Ph.D.
Professor of Cell Biology (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)

Pere Puigserver, Ph.D. is Professor of Cell Biology at Harvard Medical School and Dana-Farber Cancer Institute. He received his PhD in Biochemistry from UIB (Spain) that included research at Stockholm University, following postdoctoral work at the Dana-Farber Cancer Institute. He joined the faculty of Cell Biology at Johns Hopkins University School of Medicine in 2002 and subsequently returned in 2006 to the Department of Cell Biology (Harvard Medical School) and Cancer Biology (Dana-Farber Cancer Institute).

The Puigserver Lab focuses on the regulatory molecular mechanisms of core metabolic processes that maintain cell homeostasis and phenotypes. The research program of the Puigserver Lab includes main areas such as 1) mitochondrial biology, 2) intermediary metabolism and, 3) cancer metabolism and energetics. In mitochondrial biology, particular interests are in the regulatory mechanisms that control mitochondrial energetics and biogenesis, with implications in a variety of diseases including metabolic and mitochondrial diseases. In intermediary metabolism, a major focus is in liver and adipose cells and their regulatory mechanisms that control nutrient-derived metabolic and energetic activities. In cancer metabolism and energetics, the Puigserver Lab addresses how these processes drive core cancer biology programs such as cell growth, survival and resistance mechanisms.  The Puigserver Lab uses a multidisciplinary experimental design and approaches including chemical and genetic screens in mammalian cells, quantitative metabolomics and proteomics, biochemistry, mouse pre-clinical models of obesity/diabetes, mitochondrial diseases and cancer.    

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6213

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-582-7977

Lab fax: 617-632-5363

Atossa: a royal link between OXPHOS metabolism and macrophage migration.
Authors: Authors: Latorre-Muro P, Puigserver P.
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Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease.
Authors: Authors: Mutlu B, Puigserver P.
J Clin Invest
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Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease.
Authors: Authors: Bennett CF, Ronayne CT, Puigserver P.
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Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.
Authors: Authors: Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P.
Nat Chem Biol
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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Authors: Authors: Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, <a href="">Jedrychowski M</a>, <a href="">Gygi SP</a>, <a href="">Puigserver P</a>.
Cell Metab
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GCN5 acetyltransferase in cellular energetic and metabolic processes.
Authors: Authors: Mutlu B, Puigserver P.
Biochim Biophys Acta Gene Regul Mech
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Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production.
Authors: Authors: Lin H, Sharabi K, Lin L, Ruiz C, Zhu D, Cameron MD, Novick SJ, Griffin PR, Puigserver P, Kamenecka TM.
J Med Chem
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Tetracyclines promote survival and fitness in mitochondrial disease models.
Authors: Authors: Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P.
Nat Metab
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Transcriptome-wide analysis of PGC-1a-binding RNAs identifies genes linked to glucagon metabolic action.
Authors: Authors: Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P.
Proc Natl Acad Sci U S A
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Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.
Authors: Authors: Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavares CDJ, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P.
Cancer Res
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