Nika Danial

Nika Danial, Ph.D.

Associate Professor of Medicine (Dana-Farber Cancer Institute)
Affiliate Member of Cell Biology (HMS)

Nika Danial, Ph.D., is an Associate Professor of Cancer Biology and Medicine (DFCI) , and an affiliate member of the Cell Biology Department (HMS). She received an undergraduate degree in Biological Sciences from Stanford University, and a Ph.D. in Molecular, Cellular and Biophysical Studies from Columbia University. Her postdoctoral studies in the laboratory of Stanley J. Korsmeyer at the Dana-Farber Cancer Institute focused on the role of BCL-2 family proteins in mitochondrial apoptosis, where she discovered a molecular link between cell survival/death regulatory pathways and metabolism. She joined the faculty of the Dana-Farber Cancer Institute and Harvard Medical School in 2005.

The Danial Lab focuses on molecular mechanisms and biologic consequences of cellular fuel choices. Different cell states have distinct anabolic and catabolic needs that are fulfilled by processing specific metabolic substrates. As such, cells’ fuel choice can influence transitions in and out of quiescence, resistance/sensitivity to oxidative stress, metabolic adaptations to nutrient changes, and cell identity, including epigenetic regulation. Understanding how these fuel preferences are controlled and defining their specific metabolic outputs will provide a molecular handle on modulating cell behavior in normal physiology and in pathologic conditions. The Danial lab uses multi-disciplinary in vitro and in vivo approaches that draw on mitochondrial metabolism, biochemistry, chemical biology, proteomics, metabolomics and genetically engineered mouse models to identify molecular determinants of cellular fuel choices and their effects on cell fate and function. This research program has led to discoveries linking fuel utilization pathways to cellular stress outcomes in diseases such as cancer, diabetes and seizure disorders.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6313

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-6436

Lab Fax: 617-632-5363

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.
Authors: Authors: Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS.
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MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Authors: Authors: Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD.
Cell Rep
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Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.
Authors: Authors: Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J.
Sci Adv
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Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.
Authors: Authors: Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN.
Cell Rep
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More Metabolism!
Authors: Authors: Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K.
Mol Cell
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BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Authors: Authors: Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS.
Nat Commun
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UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Authors: Authors: Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET.
Nat Metab
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Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.
Authors: Authors: Choi DW, Roh YJ, Kim S, Lee HM, Kim M, Shin D, Park JH, Cho Y, Park HH, Ok YS, Kang D, Kim JH, Tarrago L, Danial NN, Gladyshev VN, Min PK, Lee BC.
Biosens Bioelectron
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CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.
Authors: Authors: Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH.
Sci Transl Med
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Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
Authors: Authors: Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD.
ACS Chem Biol
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