Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Astrocyte deletion of a2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Authors: Authors: Smith SE, Chen X, Brier LM, Bumstead JR, Rensing NR, Ringel AE, Shin H, Oldenborg A, Crowley JR, Bice AR, Dikranian K, Ippolito JE, Haigis MC, Papouin T, Zhao G, Wong M, Culver JP, Bonni A.
Nat Commun
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The effects of age and systemic metabolism on anti-tumor T cell responses.
Authors: Authors: Drijvers JM, Sharpe AH, Haigis MC.
Elife
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Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
Authors: Authors: van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT.
Cell Metab
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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.
Authors: Authors: Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC.
Cell Metab
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The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function.
Authors: Authors: Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi Y.
J Biol Chem
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REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
Authors: Authors: Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LW.
Genes Dev
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Nitrogen Metabolism in Cancer and Immunity.
Authors: Authors: Kurmi K, Haigis MC.
Trends Cell Biol
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Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma.
Authors: Authors: Randall EC, Lopez BGC, Peng S, Regan MS, Abdelmoula WM, Basu SS, Santagata S, Yoon H, Haigis MC, Agar JN, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR.
Cancer Res
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Leveraging insights into cancer metabolism-a symposium report.
Authors: Authors: Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W.
Ann N Y Acad Sci
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Sweet Temptation: From Sugar Metabolism to Gene Regulation.
Authors: Authors: Notarangelo G, Haigis MC.
Immunity
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