Lucas Farnung
Lucas Farnung, Ph.D.
Assistant Professor of Cell Biology (HMS)

Dr. rer. nat. Lucas Farnung is a an Assistant Professor of Cell Biology. Lucas completed his doctoral thesis at Ludwig Maximilian University of Munich (Germany) and the Max Planck Institute for Biophysical Chemistry (Germany). Lucas worked as a postdoctoral fellow and project leader at the Max Planck Institute for Biophysical Chemistry to elucidate molecular mechanisms of chromatin transcription.

The Farnung Lab investigates key mechanistic questions at the intersection of chromatin and transcription. Eukaryotic genomes are organized in a structure called chromatin that allows eukaryotic cells to compact their genomes into the small confines of the nucleus. The structure of chromatin and its fundametal unit, the nucleosome, represent a significant challenge to the transcription machinery because any molecular motor that moves through chromatin must overcome contacts between the nucleosomal DNA and the histone octamer. How this process of chromatin passage is coordinated remains unknown.

The Farnung Lab employs biochemical, biophysical, and structural biology approaches to investigate how the transcription machinery, histone modifying enzymes, chromatin remodellers, and chromatin interact to establish and retain epigenomic information during gene expression. These efforts facilitate our molecular understanding of chromatin and transcription with direct mechanistic implications for understanding cell differentiation and disease.

Harvard Medical School

Dept of Cell Biology

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-0051

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Authors: Authors: Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P.
Nat Commun
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Structure of replicating SARS-CoV-2 polymerase.
Authors: Authors: Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P.
Nature
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Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
Authors: Authors: Vos SM, Farnung L, Linden A, Urlaub H, Cramer P.
Nat Struct Mol Biol
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Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.
Authors: Authors: Farnung L, Ochmann M, Cramer P.
Elife
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Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Authors: Authors: Wang H, Farnung L, Dienemann C, Cramer P.
Nat Struct Mol Biol
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Structure of transcribing RNA polymerase II-nucleosome complex.
Authors: Authors: Farnung L, Vos SM, Cramer P.
Nat Commun
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The interaction landscape between transcription factors and the nucleosome.
Authors: Authors: Zhu F, Farnung L, Kaasinen E, Sahu B, Yin Y, Wei B, Dodonova SO, Nitta KR, Morgunova E, Taipale M, Cramer P, Taipale J.
Nature
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Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Authors: Authors: Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P.
Nature
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Structure of paused transcription complex Pol II-DSIF-NELF.
Authors: Authors: Vos SM, Farnung L, Urlaub H, Cramer P.
Nature
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Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by a-amanitin.
Authors: Authors: Liu X, Farnung L, Wigge C, Cramer P.
J Biol Chem
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