Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Authors: Authors: Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ.
Proc Natl Acad Sci U S A
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Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation.
Authors: Authors: Li Y, Lan Q, Gao Y, Xu C, Xu Z, Wang Y, Chang L, Wu J, Deng Z, He F, Finley D, Xu P.
iScience
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Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Authors: Authors: Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE.
Cell Chem Biol
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Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.
Authors: Authors: Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA.
Nat Commun
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A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.
Authors: Authors: Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.
Biochemistry
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The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates.
Authors: Authors: Martinez-Fonts K, Davis C, Tomita T, Elsasser S, Nager AR, Shi Y, Finley D, Matouschek A.
Nat Commun
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N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.
Authors: Authors: Ye Y, Klenerman D, Finley D.
J Mol Biol
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Thiol-based direct threat sensing by the stress-activated protein kinase Hog1.
Authors: Authors: Guerra-Moreno A, Prado MA, Ang J, Schnell HM, Micoogullari Y, Paulo JA, Finley D, Gygi SP, Hanna J.
Sci Signal
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The Proteasome and Its Network: Engineering for Adaptability.
Authors: Authors: Finley D, Prado MA.
Cold Spring Harb Perspect Biol
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Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme.
Authors: Authors: Cliffe R, Sang JC, Kundel F, Finley D, Klenerman D, Ye Y.
Cell Rep
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