Daniel Finley, Ph.D.
Daniel Finley, Ph.D.
Professor of Cell Biology (HMS)

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Lab Fax: 617-432-1144

Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy.
Authors: Authors: Cao C, Prado MA, Sun L, Rockowitz S, Sliz P, Paulo JA, Finley D, Fleming MD.
J Nutr
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Membrane skeleton modulates erythroid proteome remodeling and organelle clearance.
Authors: Authors: Liu Y, Mei Y, Han X, Korobova FV, Prado MA, Yang J, Peng Z, Paulo JA, Gygi SP, Finley D, Ji P.
Blood
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Global proteomics of Ubqln2-based murine models of ALS.
Authors: Authors: Whiteley AM, Prado MA, de Poot SAH, Paulo JA, Ashton M, Dominguez S, Weber M, Ngu H, Szpyt J, Jedrychowski MP, Easton A, Gygi SP, Kurz T, Monteiro MJ, Brown EJ, Finley D.
J Biol Chem
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Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA.
Authors: Authors: Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP.
J Cyst Fibros
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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Authors: Authors: Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, Finley D, Monteiro MJ.
Proc Natl Acad Sci U S A
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Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation.
Authors: Authors: Li Y, Lan Q, Gao Y, Xu C, Xu Z, Wang Y, Chang L, Wu J, Deng Z, He F, Finley D, Xu P.
iScience
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Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.
Authors: Authors: Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA.
Nat Commun
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A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.
Authors: Authors: Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.
Biochemistry
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The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates.
Authors: Authors: Martinez-Fonts K, Davis C, Tomita T, Elsasser S, Nager AR, Shi Y, Finley D, Matouschek A.
Nat Commun
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N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.
Authors: Authors: Ye Y, Klenerman D, Finley D.
J Mol Biol
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