Bradley E. Bernstein, M.D., Ph.D.
Bradley Bernstein, M.D., Ph.D.
Chair of Cancer Biology (Dana-Farber Cancer Institute)
Richard and Nancy Lubin Family Chair (DFCI)
Professor of Pathology (HMS)
Professor of Cell Biology (HMS)
LC-8313, 450 Brookline Avenue

Bradley Bernstein, M.D., Ph.D. is the Chair of Cancer Biology at the Dana-Farber Cancer Institute, where he holds the Richard and Nancy Lubin Family Chair. He is also the Director of the Gene Regulation Observatory at the Broad Institute, a Professor of Pathology and a Professor of Cell Biology at Harvard Medical School, and an Investigator in Harvard’s Ludwig Institute.

Dr. Bernstein’s research focuses on epigenetic gene regulation. The Bernstein Lab studies how gene activity is controlled by noncoding regulatory elements such as ‘enhancers’, and by the way the genes are packaged into chromatin. His work is notable for the discovery of ‘bivalent domains’, a signature chromatin state consisting of opposing histone modifications that poise master genes for alternate fates. His characterization of bivalent chromatin and associated regulatory factors in stem cells was a key early demonstration of the mechanistic impact of chromatin on mammalian development. His subsequent work as a leader of the NIH’s ENCODE consortium revealed that the vast ‘noncoding’ portions of the human genome, which had previously been dismissed as ‘junk’, are in fact packed with sequence elements that control gene activity.

Dr. Bernstein’s second major area of contribution is cancer epigenetics. He showed that DNA methylation can activate oncogenes by disrupting genomic insulators, an entirely unexpected discovery given that methylation had been so closely tied to repression. This finding explains how certain tumors can sustain potent oncogenic signaling in the absence of canonical mutations. His group has also uncovered epigenetic mechanisms that underlie tumor cell self-renewal, drug tolerance and immune evasion.

Dr. Bernstein received his B.S. from Yale University in 1992 and his M.D. and Ph.D. from the University of Washington in 1999, before completing a residency in clinical pathology at Brigham and Women’s Hospital and postdoctoral research at Harvard University.

Dana-Farber Cancer Institute

Cancer Biology/LC-8313

450 Brookline Avenue

Boston, MA 02215

Office: 617-632-5160

Author Correction: Perspectives on ENCODE.
Authors: Authors: Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, Feingold EA, Pazin MJ, Pagan M, Gilchrist DA, Hitz BC, Cherry JM, Bernstein BE, Mendenhall EM, Zerbino DR, Frankish A, Flicek P, Myers RM.
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Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes.
Authors: Authors: Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Van Nostrand EL, Freese P, Gorkin DU, Shen Y, He Y, Mackiewicz M, Pauli-Behn F, Williams BA, Mortazavi A, Keller CA, Zhang XO, Elhajjajy SI, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM, Myers RM, Ren B, Graveley BR, Gerstein MB, Pennacchio LA, Snyder MP, Bernstein BE, Wold B, Hardison RC, Gingeras TR, Stamatoyannopoulos JA, Weng Z.
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Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.
Authors: Authors: Miller TE, Lareau CA, Verga JA, DePasquale EAK, Liu V, Ssozi D, Sandor K, Yin Y, Ludwig LS, El Farran CA, Morgan DM, Satpathy AT, Griffin GK, Lane AA, Love JC, Bernstein BE, Sankaran VG, van Galen P.
Nat Biotechnol
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Systematic detection of m6A-modified transcripts at single-molecule and single-cell resolution.
Authors: Authors: Kim KL, van Galen P, Hovestadt V, Rahme GJ, Andreishcheva EN, Shinde A, Gaskell E, Jones DR, Shema E, Bernstein BE.
Cell Rep Methods
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Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells.
Authors: Authors: Shareef SJ, Bevill SM, Raman AT, Aryee MJ, van Galen P, Hovestadt V, Bernstein BE.
Nat Biotechnol
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Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Authors: Authors: Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE.
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Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL.
Authors: Authors: Anand P, Guillaumet-Adkins A, Dimitrova V, Yun H, Drier Y, Sotudeh N, Rogers A, Ouseph MM, Nair M, Potdar S, Isenhart R, Kloeber JA, Vijaykumar T, Niu L, Vincent T, Guo G, Frede J, Harris MH, Place AE, Silverman LB, Teachey DT, Lane AA, DeAngelo DJ, Aster JC, Bernstein BE, Lohr JG, Knoechel B.
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Epigenetic Alterations in Keratinocyte Carcinoma.
Authors: Authors: Yao Q, Epstein CB, Banskota S, Issner R, Kim Y, Bernstein BE, Pinello L, Asgari MM.
J Invest Dermatol
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Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
Authors: Authors: Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS.
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Serving on the Navy's Hospital Ships During the Response to COVID-19: Perspective from Two Deployed Missouri Physicians.
Authors: Authors: Dunn GP, Bernstein B.
Mo Med
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