Tobi Walther
Tobias Walther, Ph.D.
Professor of Molecular Metabolism, Harvard T.H. Chan School of Public Health
Professor of Cell Biology (HMS)
Executive Director of the Harvard T.H. Chan School of Public Health Analytics Center
Director, Center on Causes and Prevention for Cardiovascular Disease (HCSPH)
Building 1, Room 205

Tobi Walther, Ph.D., received his PhD in biology from the European Molecular Biology Laboratory and Ludwig-Maximilians University in Munich, and trained as a postdoc in the Department of Biochemistry and Biophysics at UCSF. He became a Group Leader at the Max Planck Institute of Biochemistry in Martinsried, Germany. In 2010, he relocated his lab and became Associate Professor of Cell Biology at the Yale School of Medicine. In 2014, Dr. Walther joined the Harvard Chan School of Public Health’s Department of Genetics and Complex Diseases, and studies the mechanisms of lipid and membrane homeostasis in cells and organisms with his scientific partner, Bob Farese Jr.

The Farese & Walther laboratory determines the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability and how these processes function in membrane biology and cell physiology.

Harvard T.H. Chan School of Public Health

Dept. of Genetics and Complex Diseases, Building 1, Room 205

665 Huntington Avenue

Boston, MA 02115

Lab telephone: 617-432-6259

Lab fax: 617-432-5236

Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex.
Authors: Authors: Bainter W, Platt CD, Park SY, Stafstrom K, Wallace JG, Peters ZT, Massaad MJ, Becuwe M, Salinas SA, Jones J, Beaussant-Cohen S, Jaber F, Yang JS, Walther TC, Orange JS, Rao C, Rakoff-Nahoum S, Tsokos M, Naseem SUR, Al-Tamemi S, Chou J, Hsu VW, Geha RS.
J Clin Invest
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The power of two: lessons from a scientific partnership.
Authors: Authors: Farese RV, Walther TC.
J Clin Invest
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Authors: Authors: Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ.
Nature
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A Systematic Protein Turnover Map for Decoding Protein Degradation.
Authors: Authors: Christiano R, Arlt H, Kabatnik S, Mejhert N, Lai ZW, Farese RV, Walther TC.
Cell Rep
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Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.
Authors: Authors: Chitraju C, Fischer AW, Farese RV, Walther TC.
Cell Rep
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FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
Authors: Authors: Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV.
J Cell Biol
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Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
Authors: Authors: Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV, Walther TC.
Dev Cell
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Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Authors: Authors: Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC.
Proc Natl Acad Sci U S A
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Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
Authors: Authors: Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV.
Nature
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Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.
Authors: Authors: Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC.
Mol Cell
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