Robert V. Farese, Jr., Ph.D.
Robert V. Farese, Jr., M.D.
Professor of Molecular Metabolism (Harvard T.H. Chan School of Public Health)
Professor of Cell Biology (HMS)
Building 1, Room 207A

Robert Farese, Jr., M.D., Professor of Molecular Metabolism in the Department of Molecular Metabolism at Harvard Chan School of Public Health, and Professor of Cell Biology at Harvard Medical School, where he runs a laboratory jointly since 2014 with Dr. Tobias Walther. Dr. Farese obtained his M.D. from Vanderbilt University, did medical training at the University of Colorado, and his postdoctoral research training at UCSF and the Gladstone Institutes. Dr. Farese was an investigator at Gladstone/UCSF from 1994-2014, where his laboratory focused on lipid and energy metabolism, in particular elucidating the biochemical and cell biological pathways of neutral lipid and triglyceride synthesis and storage. Since 2007, Dr. Farese also works in the field of neurodegenerative diseases, with an emphasis on investigating lipid metabolism in the central nervous system. He serves on the board of the Bluefield Project to Cure FTD.

The Farese & Walther Lab investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly the lab studies the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability, and how these processes function in membrane biology and cell physiology.

Harvard T.H. Chan School of Public Health

Dept. of Genetics and Complex Diseases, Building 1, Room 207A

665 Huntington Avenue

Boston, MA 02115

Lab Phone: 617-432-6259

Lab Fax: 617-432-5236

Seipin forms a flexible cage at lipid droplet formation sites.
Authors: Authors: Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC.
Nat Struct Mol Biol
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The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.
Authors: Authors: Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC.
Dev Cell
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Key Factors Governing Initial Stages of Lipid Droplet Formation.
Authors: Authors: Kim S, Li C, Farese RV, Walther TC, Voth GA.
J Phys Chem B
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The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting.
Authors: Authors: Olarte MJ, Swanson JMJ, Walther TC, Farese RV.
Trends Biochem Sci
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Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues.
Authors: Authors: Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature
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An open-access volume electron microscopy atlas of whole cells and tissues.
Authors: Authors: Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF.
Nature
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Conditional targeting of phosphatidylserine decarboxylase to lipid droplets.
Authors: Authors: Kumar S, Chitraju C, Farese RV, Walther TC, Burd CG.
Biol Open
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Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus.
Authors: Authors: Sajan MP, Hansen BC, Acevedo-Duncan M, Kindy MS, Cooper DR, Farese RV.
MedComm (2020)
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The power of two: lessons from a scientific partnership.
Authors: Authors: Farese RV, Walther TC.
J Clin Invest
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Control of ß-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-?/? and Nuclear Factor ?-B.
Authors: Authors: Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV.
Curr Alzheimer Res
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