Robert V. Farese, Jr., Ph.D.
Robert V. Farese, Jr., M.D.
Professor of Molecular Metabolism (Harvard T.H. Chan School of Public Health)
Professor of Cell Biology (HMS)
Building 1, Room 207A

Robert Farese, Jr., M.D., Professor of Molecular Metabolism in the Department of Molecular Metabolism at Harvard Chan School of Public Health, and Professor of Cell Biology at Harvard Medical School, where he runs a laboratory jointly since 2014 with Dr. Tobias Walther. Dr. Farese obtained his M.D. from Vanderbilt University, did medical training at the University of Colorado, and his postdoctoral research training at UCSF and the Gladstone Institutes. Dr. Farese was an investigator at Gladstone/UCSF from 1994-2014, where his laboratory focused on lipid and energy metabolism, in particular elucidating the biochemical and cell biological pathways of neutral lipid and triglyceride synthesis and storage. Since 2007, Dr. Farese also works in the field of neurodegenerative diseases, with an emphasis on investigating lipid metabolism in the central nervous system. He serves on the board of the Bluefield Project to Cure FTD.

The Farese & Walther Lab investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly the lab studies the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation in their availability, and how these processes function in membrane biology and cell physiology.

Harvard T.H. Chan School of Public Health

Dept. of Genetics and Complex Diseases, Building 1, Room 207A

665 Huntington Avenue

Boston, MA 02115

Lab Phone: 617-432-6259

Lab Fax: 617-432-5236

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
Authors: Authors: Chitraju C, Walther TC, Farese RV.
J Lipid Res
View full abstract on Pubmed
Hepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis.
Authors: Authors: Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC.
View full abstract on Pubmed
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
Authors: Authors: Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV.
Mol Cell
View full abstract on Pubmed
Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Authors: Authors: Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.
Mol Cell
View full abstract on Pubmed
Atypical PKC: therapeutic target for Alzheimer's?
Authors: Authors: Farese RV, Sajan MP.
Aging (Albany NY)
View full abstract on Pubmed
Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.
Authors: Authors: Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC.
J Cell Biol
View full abstract on Pubmed
Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
Authors: Authors: Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV.
View full abstract on Pubmed
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Authors: Authors: Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC.
Mol Biol Cell
View full abstract on Pubmed
Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.
Authors: Authors: Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV.
Mol Cell Proteomics
View full abstract on Pubmed
Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Authors: Authors: Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV.
Proc Natl Acad Sci U S A
View full abstract on Pubmed