Maofu Liao
Maofu Liao, Ph.D.
Associate Professor of Cell Biology (HMS)

Maofu Liao, Ph.D., is an Associate Professor of Cell Biology at Harvard Medical School. He received his Ph.D. from Albert Einstein College of Medicine in 2006, performed postdoctoral research at University of California, San Francisco, and joined the faculty in the Department of Cell Biology of Harvard Medical School in 2014. 

Research in the Liao Lab focuses on understanding the structure and function of membrane proteins and DNA/RNA-protein complexes. The major techniques include single-particle cryo-electron microscopy (cryo-EM) and a variety of biochemical assays. The Liao lab is particularly interested to reveal the mechanism of how proteins sense, move and convert specific lipid molecules. This is achieved by obtaining high-resolution structures of lipid-interacting proteins, and by studying the conformational dynamics of membrane proteins in lipid bilayer environment.

Harvard Medical School

Dept. of Cell Biology, SGM 629A

240 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-4013

The ABCs of Sterol Transport.
Authors: Authors: Plummer AM, Culbertson AT, Liao M.
Annu Rev Physiol
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Bedaquiline inhibits the yeast and human mitochondrial ATP synthases.
Authors: Authors: Luo M, Zhou W, Patel H, Srivastava AP, Symersky J, Bonar MM, Faraldo-Gómez JD, Liao M, Mueller DM.
Commun Biol
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High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC.
Authors: Authors: Thélot F, Orlando BJ, Li Y, Liao M.
Curr Opin Struct Biol
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Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Authors: Authors: Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L.
Nature
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ABCG2 transports anticancer drugs via a closed-to-open switch.
Authors: Authors: Orlando BJ, Liao M.
Nat Commun
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Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
Authors: Authors: Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV.
Nature
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Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
Authors: Authors: Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA.
Science
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Structure and mechanism of the cation-chloride cotransporter NKCC1.
Authors: Authors: Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L.
Nature
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Large protein organelles form a new iron sequestration system with high storage capacity.
Authors: Authors: Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA.
Elife
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Structural basis of lipopolysaccharide extraction by the LptB2FGC complex.
Authors: Authors: Li Y, Orlando BJ, Liao M.
Nature
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