Fred Goldberg
Alfred Goldberg, Ph.D.
Professor of Cell Biology, Emeritus (HMS)
C-415A
617-432-1855
Goldberg Lab

Fred Goldberg, Ph.D., did both undergraduate and graduate work at Harvard, and was appointed to a faculty position in the Department of Physiology, and later, in the Department of Molecular and Cellular Physiology, which were precursors to today's Department of Cell Biology. He has received many honors for his pioneering work, including the discoveries of the uniquitin-protesome pathway and ATP-dependent proteases. His research resulted in the development of proteosome inhibitors, including bortezomib/Velcade, used worldwide as the primary treatment for multiple myeloma.

The Goldberg laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.

Harvard Medical School

Dept. of Cell Biology, C-415A

240 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1855

Lab fax: 617-432-1144

Faculty Assistant

Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy.
Authors: Authors: VerPlank JJS, Gawron J, Silvestri NJ, Feltri ML, Wrabetz L, Goldberg AL.
Brain
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Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation.
Authors: Authors: Collins GA, Sha Z, Kuo CL, Erbil B, Goldberg AL.
J Biol Chem
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Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation.
Authors: Authors: Goldberg AL, Kim HT, Lee D, Collins GA.
Biomolecules
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ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Authors: Authors: Kester JC, Kandror O, Akopian T, Chase MR, Zhu J, Rubin EJ, Goldberg AL, Fortune SM.
J Bacteriol
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Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis.
Authors: Authors: Sha Z, Goldberg AL.
Proc Natl Acad Sci U S A
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cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases.
Authors: Authors: VerPlank JJS, Tyrkalska SD, Fleming A, Rubinsztein DC, Goldberg AL.
Proc Natl Acad Sci U S A
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An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Authors: Authors: Vahidi S, Ripstein ZA, Juravsky JB, Rennella E, Goldberg AL, Mittermaier AK, Rubinstein JL, Kay LE.
Proc Natl Acad Sci U S A
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Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation.
Authors: Authors: Collins GA, Goldberg AL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.
Authors: Authors: Sha Z, Blyszcz T, González-Prieto R, Vertegaal ACO, Goldberg AL.
J Biol Chem
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SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
Authors: Authors: Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB.
Proc Natl Acad Sci U S A
View full abstract on Pubmed