Fred Goldberg
Alfred Goldberg, Ph.D.
Professor of Cell Biology (HMS)

Fred Goldberg, Ph.D., did both undergraduate and graduate work at Harvard, and was appointed to a faculty position in the Department of Physiology, and later, in the Department of Molecular and Cellular Physiology, which were precursors to today's Department of Cell Biology. He has received many honors for his pioneering work, including the discoveries of the uniquitin-protesome pathway and ATP-dependent proteases. His research resulted in the development of proteosome inhibitors, including bortezomib/Velcade, used worldwide as the primary treatment for multiple myeloma.

The Goldberg laboratory is presently studying the regulation and mechanisms of protein breakdown in animal and bacterial cells.

Harvard Medical School

Dept. of Cell Biology, C-415A

240 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1855

Lab fax: 617-432-1144

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Authors: Authors: Kester JC, Kandror O, Akopian T, Chase MR, Zhu J, Rubin EJ, Goldberg AL, Fortune SM.
J Bacteriol
View full abstract on Pubmed
Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis.
Authors: Authors: Sha Z, Goldberg AL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases.
Authors: Authors: VerPlank JJS, Tyrkalska SD, Fleming A, Rubinsztein DC, Goldberg AL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Authors: Authors: Vahidi S, Ripstein ZA, Juravsky JB, Rennella E, Goldberg AL, Mittermaier AK, Rubinstein JL, Kay LE.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation.
Authors: Authors: Collins GA, Goldberg AL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.
Authors: Authors: Sha Z, Blyszcz T, González-Prieto R, Vertegaal ACO, Goldberg AL.
J Biol Chem
View full abstract on Pubmed
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
Authors: Authors: Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
Authors: Authors: Zhang H, Pan B, Wu P, Parajuli N, Rekhter MD, Goldberg AL, Wang X.
Sci Adv
View full abstract on Pubmed
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Authors: Authors: VerPlank JJS, Lokireddy S, Zhao J, Goldberg AL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis.
Authors: Authors: Fraga H, Rodriguez B, Bardera A, Cid C, Akopian T, Kandror O, Park A, Colmenarejo G, Lelievre J, Goldberg A.
Anal Biochem
View full abstract on Pubmed